News Release Details

Peregrine Pharmaceuticals Reports Financial Results for the Third Quarter of Fiscal Year 2008

March 11, 2008 at 12:00 AM EDT

TUSTIN, Calif., March 11, 2008 /PRNewswire-FirstCall via COMTEX News Network/ -- Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a clinical stage biopharmaceutical company developing monoclonal antibodies for the treatment of cancer and hepatitis C virus (HCV) infection, today announced financial results for the third quarter of fiscal year (FY) 2008 ended January 31, 2008. The company reported a consolidated net loss of $6,154,000, or $0.03 per basic and diluted share, compared to a consolidated net loss of $5,025,000 or $0.03 per basic and diluted share for the same prior year period. The increased net loss primarily reflects increased investments in research and development as the company advanced its clinical programs for bavituximab and Cotara(R).

Total revenues for the current quarter increased to $1,675,000 compared to $363,000 for the comparable quarter last year, and were primarily generated from services provided by Avid Bioservices, the company's wholly owned contract manufacturing subsidiary.

Total costs and expenses increased to $8,077,000 in the third quarter of FY 2008 from $5,643,000 in the same prior year quarter. The increase was primarily related to the increase in the cost of contract manufacturing of $1,066,000 during the quarter resulting from higher reported revenues from external customers, in addition to the increase in research and development expenses of $1,034,000 associated with the advancement of the company's clinical and preclinical product candidates. Research and development expenses were $4,941,000 in the third quarter of FY 2008, compared to $3,907,000 in the third quarter of FY 2007. At January 31, 2008, the company had $20,063,000 in cash and cash equivalents compared to $16,044,000 at fiscal year end April 30, 2007.

"The past quarter was highlighted by a major milestone in our oncology program, as we dosed the first patients in a Phase II trial evaluating bavituximab in combination with chemotherapy in patients with breast cancer," said Steven W. King, president and CEO of Peregrine. "We also received regulatory approval to initiate two additional bavituximab Phase II cancer trials -- a second breast cancer study and a trial in patients with non-small cell lung cancer, a leading cause of cancer deaths worldwide. Planning for these trials is well underway and we anticipate initiating both studies next month. We also made progress in our Cotara clinical program in patients with glioblastoma multiforme (GBM), today announcing promising data from the ongoing dosimetry and Phase II trials showing that several patients are already surviving longer than the expected six-month median survival time for this patient population, with the longest surviving patient now at 15 months post-treatment. Patients who are continuing in the trials are being monitored for safety and overall survival, and we look forward to providing further updates on these trials going forward. We have also recently expanded the number of clinical sites in the Phase Il study to eight and also added a distinguished brain cancer center and experienced Cotara clinical study site -- the Barrow Neurological Institute -- to our dosimetry study in the U.S."

Mr. King added, "Our initiative to raise awareness for the bavituximab and Cotara programs in the scientific and medical communities scored gains, including an oral presentation covering the clinical experience to date in the bavituximab Phase I cancer program at Angio 2008, an oral presentation of clinical data from our Phase I bavituximab trial in hepatitis C patients at the prestigious 2007 Liver Meeting(R), a recent publication in Clinical Cancer Research highlighting bavituximab's ability to target tumor blood vessels with excellent specificity, and the acceptance last week of an abstract discussing patient data from the Cotara dosimetry trial for presentation at the 2008 ASCO Annual Meeting. We anticipate additional high profile scientific publications and presentations in the coming months while we continue making good progress in advancing our trio of Phase II bavituximab cancer trials, the two ongoing Cotara clinical trials and the trial of bavituximab in HCV patients co-infected with HIV. We look forward to a steady flow of news from these multiple activities in the coming months."

Recent Highlights

Bavituximab Anti-Cancer Program: The company launched the Phase II cancer clinical program for bavituximab during the quarter and achieved a number of other clinical and preclinical advancements.

    --  Initiated patient dosing in a Phase II combination therapy trial of
        bavituximab and docetaxel in patients with advanced breast cancer
        within 14 days of study initiation.
    --  Received regulatory approval to begin two additional Phase II
        bavituximab combination therapy trials -- one in combination with
        carboplatin and paclitaxel in patients with advanced breast cancer and
        another in combination with carboplatin plus paclitaxel in patients
        with non-small cell lung cancer (NSCLC).  Both trials are preparing to
        begin enrolling patients shortly.
    --  A bavituximab cancer investigator presented data at a leading
        scientific meeting on anti-angiogenic agents -- the 10th Annual
        International Symposium on Anti-Angiogenic Agents (Angio 2008) --
        highlighting the positive clinical experience to date with
        bavituximab.
    --  A preclinical study published in Clinical Cancer Research confirmed
        bavituximab's ability to target tumor blood vessels with excellent
        specificity.  The high degree of selective targeting seen in the study
        provides additional evidence of bavituximab's therapeutic potential.


Bavituximab Anti-Viral Program: During the third quarter, the company continued to advance its bavituximab HCV program and presented positive data at a key liver disease meeting.

    --  Added The Johns Hopkins Hospital and a private clinic in Orange
        County, California as additional clinical study sites for the HCV/HIV
        co-infection study.
    --  Presented final results from the Phase I multiple dose HCV trial at
        the prestigious Annual Meeting of the American Association for the
        Study of Liver Disease that showed bavituximab was well tolerated and
        demonstrated encouraging signs of anti-viral activity.


Cotara(R) Glioblastoma Program: Peregrine continued to advance the Cotara brain cancer program.

    --  Added additional study sites and continued patient dosing and
        follow-up in the Cotara Phase II study in patients with glioblastoma
        multiforme, the most deadly form of brain cancer.  Eight sites are now
        open for patient enrollment.
    --  Added an additional site, the Barrow Neurological Institute (BNI) in
        Phoenix, Arizona, to the ongoing Cotara dosimetry and dose
        confirmation clinical study.  BNI also participated in a previous
        Cotara Phase II clinical trial.
    --  Announced positive results from the first cohort of patients treated
        in the Cotara dosimetry trial and from the initial patients treated in
        the Cotara Phase II trial.  Cotara appeared safe and well tolerated
        with no dose-limiting adverse events, with continuing patients being
        monitored for overall survival.  Several patients in these studies
        have lived longer than the six-month expected median survival time for
        this patient population.


    Other Preclinical Programs:
    --  Preclinical data presented at the 5th Annual International
        Anti-Angiogenesis Conference confirmed that Peregrine's fully human,
        selective anti-VEGF antibody R84 was as effective as Avastin(R) in
        inhibiting tumor growth in a model of human breast cancer.  Selective
        anti-VEGF agents may have potential advantages over non-selective
        approaches.


    Avid Bioservices:
    --  Wholly owned manufacturing subsidiary Avid Bioservices signed an
        agreement with ARIUS Research to produce clinical supplies of their
        lead cancer stem cell anti-CD44 antibody.
    --  Avid continued to demonstrate strong revenue performance during the
        third quarter of fiscal year 2008.


Conference Call

The company will host a conference call today, March 11, 2008 at 11:30 a.m. EDT/8:30 a.m. PDT to discuss its third quarter FY 2008 financial results.

To listen to a live broadcast of the call over the Internet or to review the archived call, please visit: http://www.peregrineinc.com. The webcast will be archived on Peregrine's website for approximately 30 days.

To listen to the conference call via telephone, please call the following number approximately 10 minutes prior to the scheduled start time and request to join the Peregrine Pharmaceuticals call: 1 (800) 860-2442. A telephonic replay of the conference call will be available starting approximately one hour after the conclusion of the call through March 18, 2008 by calling (877) 344-7529, passcode 382933#.

About Peregrine Pharmaceuticals

Peregrine Pharmaceuticals, Inc. is a biopharmaceutical company with a portfolio of innovative product candidates in clinical trials for the treatment of cancer and hepatitis C virus (HCV) infection. The company is pursuing three separate clinical programs in cancer and HCV infection with its lead product candidates bavituximab and Cotara(R). Peregrine also has in-house manufacturing capabilities through its wholly owned subsidiary Avid Bioservices, Inc. (http://www.avidbio.com), which provides development and bio-manufacturing services for both Peregrine and outside customers. Additional information about Peregrine can be found at http://www.peregrineinc.com.

Safe Harbor Statement: Statements in this press release which are not purely historical, including statements regarding Peregrine Pharmaceuticals' intentions, hopes, beliefs, expectations, representations, projections, plans or predictions of the future are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. The forward-looking statements involve risks and uncertainties including, but not limited to the risk that the company may experience delays in clinical trial patient enrollment, the risk that future clinical trial results may not correlate with the results of prior clinical trials and preclinical studies, the risk that Avid's revenue growth may slow or decline, the risk that future protocol submissions may not be approved, the risk that the company may not be able to monetize any of its assets, the risk that the company will not regain compliance with the Nasdaq Stock Market minimum bid price requirement by July 21, 2008, and the risk that the company will not have additional high profile scientific publications and presentations. It is important to note that the company's actual results could differ materially from those in any such forward-looking statements. Factors that could cause actual results to differ materially include, but are not limited to, uncertainties associated with completing preclinical and clinical trials for our technologies; the early stage of product development; the significant costs to develop our products as all of our products are currently in development, preclinical studies or clinical trials; obtaining additional financing to support our operations and the development of our products; obtaining regulatory approval for our technologies; anticipated timing of regulatory filings and the potential success in gaining regulatory approval and complying with governmental regulations applicable to our business. Our business could be affected by a number of other factors, including the risk factors listed from time to time in the Company's SEC reports including, but not limited to, the annual report on Form 10-K for the year ended April 30, 2007 and the quarterly report on Form 10-Q for the third fiscal quarter ended January 31, 2008. The company cautions investors not to place undue reliance on the forward-looking statements contained in this press release. Peregrine Pharmaceuticals, Inc. disclaims any obligation, and does not undertake to update or revise any forward-looking statements in this press release.

     Contacts:
     GendeLLindheim BioCom Partners
     Investors                                        Media
     info@peregrineinc.com                            Barbara Lindheim
     (800) 987-8256                                   (212) 918-4650

                         -financial tables to follow-



    PEREGRINE PHARMACEUTICALS, INC.

    CONDENSED CONSOLIDATED BALANCE SHEETS


                                                 JANUARY 31,     APRIL 30,
                                                     2008          2007
                                                  Unaudited
    ASSETS

    CURRENT ASSETS:
    Cash and cash equivalents                    $20,063,000    $16,044,000
    Trade and other receivables                    1,316,000        750,000
    Inventories, net                               2,394,000      1,916,000
    Prepaid expenses and other current assets      1,140,000      1,188,000

        Total current assets                      24,913,000     19,898,000

    PROPERTY:
    Leasehold improvements                           669,000        646,000
    Laboratory equipment                           3,756,000      3,533,000
    Furniture, fixtures and office equipment         913,000        873,000

                                                   5,338,000      5,052,000
    Less accumulated depreciation and
     amortization                                 (3,537,000)    (3,212,000)

        Property, net                              1,801,000      1,840,000

    Other assets                                   1,527,000      1,259,000

    TOTAL ASSETS                                 $28,241,000    $22,997,000



    PEREGRINE PHARMACEUTICALS, INC.

    CONDENSED CONSOLIDATED BALANCE SHEETS (continued)


                                                  JANUARY 31,     APRIL 30,
                                                     2008           2007
                                                   Unaudited
    LIABILITIES AND STOCKHOLDERS' EQUITY

    CURRENT LIABILITIES:
    Accounts payable                              $2,387,000     $1,683,000
    Accrued clinical trial site fees                 244,000        228,000
    Accrued legal and accounting fees                390,000        392,000
    Accrued royalties and license fees               124,000        337,000
    Accrued payroll and related costs                858,000        874,000
    Notes payable, current portion                         -        379,000
    Capital lease obligation, current portion         17,000         17,000
    Deferred revenue                               1,434,000      1,060,000
    Other current liabilities                      1,239,000        885,000

        Total current liabilities                  6,693,000      5,855,000

    Notes payable, less current portion                    -        119,000
    Capital lease obligation, less current portion    17,000         30,000
    Deferred license revenue                               -          4,000
    Commitments and contingencies

    STOCKHOLDERS' EQUITY:
    Preferred stock-$.001 par value;
     authorized 5,000,000 shares; non-voting;
     nil shares outstanding                                -              -

    Common stock-$.001 par value; authorized
     325,000,000 shares; outstanding -
     226,210,617 and 196,112,201, respectively       226,000        196,000
    Additional paid-in capital                   245,982,000    224,453,000
    Accumulated deficit                         (224,677,000)  (207,660,000)

        Total stockholders' equity                21,531,000     16,989,000

    TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY   $28,241,000    $22,997,000



    PEREGRINE PHARMACEUTICALS, INC.

    CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS


                           THREE MONTHS ENDED          NINE MONTHS ENDED
                        January 31,  January 31,   January 31    January 31,
                           2008         2007         2008            2007
                         Unaudited    Unaudited    Unaudited      Unaudited
    REVENUES:
    Contract
     manufacturing
     revenue            $1,662,000     $347,000     $5,146,000    $1,381,000
    License revenue         13,000       16,000         46,000        87,000
      Total revenues     1,675,000      363,000      5,192,000     1,468,000

    COSTS AND EXPENSES:
    Cost of contract
     manufacturing       1,289,000      223,000      3,872,000     1,247,000
    Research and
     development         4,941,000    3,907,000     13,665,000    11,868,000
    Selling, general
     and administrative  1,847,000    1,513,000      5,498,000     4,824,000

      Total costs
       and expenses      8,077,000    5,643,000     23,035,000    17,939,000

    LOSS FROM
     OPERATIONS         (6,402,000)  (5,280,000)   (17,843,000)  (16,471,000)

    OTHER INCOME
     (EXPENSE):
    Interest and
     other income          259,000      267,000        851,000       955,000
    Interest and
     other expense         (11,000)     (12,000)       (25,000)      (36,000)

    NET LOSS           $(6,154,000) $(5,025,000)  $(17,017,000) $(15,552,000)

    WEIGHTED AVERAGE
     COMMON SHARES
     OUTSTANDING:
      Basic and
       Diluted         226,210,617  195,299,586    219,497,601   191,067,145

    BASIC AND DILUTED
     LOSS PER COMMON
     SHARE                  $(0.03)      $(0.03)        $(0.08)       $(0.08)


SOURCE Peregrine Pharmaceuticals, Inc.

http://www.peregrineinc.com

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